Author's response to reviews Title: Effects of Delta40p53, an isoform of p53 lacking the N-terminus, on transactivation capacity of the tumor suppressor protein p53. Authors:
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اثر هشت هفته تمرینات ترکیبی بر توان هوازی و سطح سرمیپروتئین سرکوبگر تومور P53 در بیماران مبتلا به سرطان پروستات: یک کارآزمایی بالینی
Background and Objectives: Physical activity plays a useful role in maintaining and improving the quality of life of men suffering from prostate cancer. The presence of tumor suppressor proteins including P53 is one of the regulatory mechanisms in controlling the progression of the disease. The purpose of this study was to investigate the effect of eight-week concurrent training on aerobic capa...
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Curcumin is a natural substance with anti-cancerous properties without many disadvantages of currently-used anticancer drugs. Its toxicity is significantly higher in tumor cells compared with normal cells. We hypothesized the difference of p53 function between normal and tumor cells as one of the presumable causes of this phenomenon. We knocked down the expression of p53 in normal fibrobl...
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The gene TP53 (also known as protein 53 or tumor protein 53), encoding transcription factor P53, is mutated or deleted in half of human cancers, demonstrating the crucial role of P53 in tumor suppression. There are reports of nearly 250 independent germ line TP53 mutations in over 100 publications. The P53 protein has the structure of a transcription factor and, is made up of several domains. T...
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Background and Objective: P53 is a suppressive gene that plays a key role in DNA repair and apoptosis. The purpose of this study was to investigate the effect of P53 protein over-expression and some clinicopathological factors on the esophageal squamous cell carcinoma (SCC) response to neoadjuvant chemoradiotherapy. Patients and Methods: In this retrospective cohort study, 44 patients with loc...
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تاریخ انتشار 2013